Publications

Primary Publication on the Hydra AEP Genome Project

• Cazet, J.F., Siebert, S., Little, H.M., Bertemes, P., Primack, A.S., Ladurner, P., Achrainer, M., Fredriksen, M.T., Moreland, R.T., Singh, S., Zhang, S., Wolfsberg, T.G., Schnitzler, C.E., Baxevanis, A.D., Simakov, A., Hobmayer, B., and Juliano, C.E. A chromosome-scale epigenetic map of the Hydra genome reveals conserved regulators of cell state. Genome Res. 2023, 33: 283-298. [PMID: 36639202]

Hydra Publications

• Browne, E. The production of new hydranths in Hydra by the insertion of small grafts. Journal of Experimental Zoology. 1909, 7(1): 1-23. [doi: 10.1002/jez.1400070102]
• Bode, H.R., Heimfeld, S., Chow, M.A., Huang, L.W. Gland cells arise by differentiation from interstitial cells in Hydra attenuata. Dev Biol. 1987 Aug, 122(2):577-85. [PMID: 3596022]
• Boehm, A.M., Khalturin, K., Anton-Erxleben, F., Hemmrich, G., Klostermeier, U.C., Lopez-Quintero, J.A., Oberg, H.H., Puchert, M., Rosenstiel, P., Wittlieb, J., Bosch, T.C. FoxO is a critical regulator of stem cell maintenance in immortal Hydra. Proc Natl Acad Sci USA. 2012 Nov 27, 109(48):19697-702. [PMCID: 23150562]
• Bosch, T.C.G., David, C.N. Male and female stem cells and sex reversal in Hydra polyps. Proc Natl Acad Sci USA. 1986 Dec, 83(24):9478-82. [PMCID: PMC387163]
• Bosch, T.C.G., David, C.N. Stem cells of Hydra magnipapillata can differentiate into somatic cells and germ line cells. Dev Biol. 1986 Dec, 121(1):182-91. [doi: 10.1016/0012-1606(87)90151-5]
• Broun, M., Gee, L., Reinhardt, B., Bode, H.R. Formation of the head organizer in Hydra involves the canonical Wnt pathway. Development. 2005 Jun, 132(12):2907-16. [PMID: 15930119]
• Campbell, R.D., David, C.N. Cell cycle kinetics and development of Hydra attenuata. II. Interstitial cells. J Cell Sci. 1974 Nov, 16(2):349-58. [PMID: 4448825]
• Chapman, J.A., Kirkness, E.F., Simakov, O., Hampson, S.E., Mitros, T., Weinmaier, T., Rattei, T., Balasubramanian, P.G., Borman, J., Busam, D., Disbennett, K., Pfannkoch, C., Sumin, N., Sutton, G.G., Viswanathan, L.D., Walenz, B., Goodstein, D.M., Hellsten, U., Kawashima, T., Prochnik, S.E., Putnam, N.H., Shu, S., Blumberg, B., Dana, C.E., Gee, L., Kibler, D.F., Law, L., Lindgens, D., Martinez, D.E., Peng, J., Wigge, P.A., Bertulat, B., Guder, C., Nakamura, Y., Ozbek, S., Watanabe, H., Khalturin, K., Hemmrich, G., Franke, A., Augustin, R., Fraune, S., Hayakawa, E., Hayakawa, S., Hirose, M., Hwang, J.S., Ikeo, K., Nishimiya-Fujisawa, C., Ogura, A., Takahashi, T., Steinmetz, P.R., Zhang, X., Aufschnaiter, R., Eder, M.K., Gorny, A.K., Salvenmoser, W., Heimberg, A.M., Wheeler, B.M., Peterson, K.J., Böttger, A., Tischler, P., Wolf, A., Gojobori, T., Remington, K.A., Strausberg, R.L., Venter, J.C., Technau, U., Hobmayer, B., Bosch, T.C., Holstein, T.W., Fujisawa, T., Bode, H.R., David, C.N., Rokhsar, D.S., Steele, R.E. The dynamic genome of Hydra. Nature. 2010 Mar 25, 464(7288):592-6. [PMCID: PMC4479502]
• David, C.N. Interstitial stem cells in Hydra: multipotency and decision-making. Int J Dev Biol. 2012, 56(6-8):489-97. [PMID: 22689367]
• David, C.N., Murphy, S. Characterization of interstitial stem cells in Hydra by cloning. Dev Biol. 1977 Jul 15, 58(2):372-83. [PMID: 328331]
• Gee, L., Hartig, J., Law, L., Wittlieb, J., Khalturin, K., Bosch, T.C., Bode, H.R. Beta-catenin plays a central role in setting up the head organizer in Hydra. Dev Biol. 2010 Apr 1, 340(1):116-24. [PMID: 20045682]
• Gierer, A., Berking, S., Bode, H., David, C.N., Flick, K., Hansmann, G., Schaller, H., Trenkner, E. Regeneration of Hydra from reaggregated cells. Nat New Biol. 1972 Sep 27, 239(91):98-101. [PMID: 4507522]
• Gierer, A., Meinhardt, H. A theory of biological pattern formation. Kybernetik. 1972 Dec, 12(1):30-9. [PMID: 4663624]
• Gufler, S., Artes, B., Bielen, H., Krainer, I., Eder, M.K., Falschlunger, J., Bollmann, A., Ostermann, T., Valovka, T., Hartl, M., Bister, K., Technau, U., Hobmayer, B. β-Catenin acts in a position-independent regeneration response in the simple eumetazoan Hydra. Dev Biol. 2018 Jan 15, 433(2):310-323. [PMID: 29108673]
• Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C.M., von Laue, C.C., Snyder, P., Rothbächer, U., Holstein, T.W. WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra. Nature. 2000 Sep 14, 407(6801):186-9. [PMID: 11001056]
• Juliano, C.E., Reich, A., Liu, N., Götzfried, J., Zhong, M., Uman, S., Reenan, R.A., Wessel, G.M., Steele, R.E., Lin, H. PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proc Natl Acad Sci USA. 2014 Jan 7, 111(1):337-42. [PMCID: PMC3890812]
• Käsbauer, T., Towb, P., Alexandrova, O., David, C.N., Dall'armi, E., Staudigl, A., Stiening, B., Böttger, A. The Notch signaling pathway in the cnidarian Hydra. Dev Biol. 2007 Mar 1, 303(1):376-90. [PMID: 17184766]
• Khalturin, K., Anton-Erxleben, F., Sassmann, S., Wittlieb, J., Hemmrich, G., Bosch, T.C. A novel gene family controls species-specific morphological traits in Hydra. PLoS Biol. 2008 Nov 18, 6(11):e278. [PMCID: PMC2586386]
• MacWilliams, H.K. Hydra transplantation phenomena and the mechanism of Hydra head regeneration. I. Properties of the head inhibition. Dev Biol. 1983 Mar, 96(1):217-38. [PMID: 6825954]
• MacWilliams, H.K. Hydra transplantation phenomena and the mechanism of Hydra head regeneration. II. Properties of the head activation. Dev Biol. 1983 Mar, 96(1):239-57. [PMID: 6825956]
• Martínez, D.E. Mortality patterns suggest lack of senescence in Hydra. Exp Gerontol. 1998 May, 33(3):217-25. [PMID: 9615920]
• Schaible, R., Scheuerlein, A., Dańko, M.J., Gampe, J., Martínez, D.E., Vaupel, J.W. Constant mortality and fertility over age in Hydra. Proc Natl Acad Sci USA. 2015 Dec 22, 112(51):15701-6. [PMCID: PMC4697432]
• Siebert, S., Farrell, J.A., Cazet, J.F., Abeykoon, Y., Primack, A.S., Schnitzler, C.E., Juliano, C.E. Stem cell differentiation trajectories in Hydra resolved at single-cell resolution. Science. 2019 Jul 26, 365(6451):eaav9314. [PMCID: PMC7104783]
• Sudhop, S., Coulier, F., Bieller, A., Vogt, A., Hotz, T., Hassel, M. Signalling by the FGFR-like tyrosine kinase, Kringelchen, is essential for bud detachment in Hydra vulgaris. Development. 2004 Aug, 131(16):4001-11. [PMID: 15269170]
• Vogg, M.C., Beccari, L., Iglesias, OllÉ, L., Rampon, C., Vriz, S., Perruchoud, C., Wenger, Y., Galliot, B. An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra. Nat Commun. 2019 Jan 18, 10(1):312. [PMCID: PMC6338789]
• Watanabe, H., Schmidt, H.A., Kuhn, A., Höger, S.K., Kocagöz, Y., Laumann-Lipp, N., Ozbek, S., Holstein, T.W. Nodal signalling determines biradial asymmetry in Hydra. Nature. 2014 Nov 6, 515(7525):112-5. [PMID: 25156256]
• Wittlieb, J., Khalturin, K., Lohmann, J.U., Anton-Erxleben, F., Bosch, T.C. Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis. Proc Natl Acad Sci USA. 2006 Apr 18, 103(16):6208-11. [PMCID: PMC1458856]